(New animal husbandry news from Luoyang) At present, my country's poultry breeding industry is rapidly moving towards "scale, standardization, intelligence and ecologicalization", but the epidemics continue, the preventive and health care medication is disordered, and the vaccine immunity is complicated. It is still a problem that plagues the rapid development of the poultry breeding industry. How to "scientifically reduce the burden and healthy breeding" is a topic that the industry needs urgent attention to.

On July 6, 2017, Luoyang Huizhong Biological Technology Co., Ltd. (hereinafter referred to as Huizhong Biological) held in Luoyang, Henan, a forum on new models of cost-saving and efficiency-enhancing immunization and the listing of new methods with the theme of "Scientific Burden Reduction, Win-Win Cooperation" At the press conference, about 200 industry professionals, experts, scholars, and media personnel from all over the country were invited to interpret the new model of poultry disease prevention and control, and explore new trends in the research and development of biological products for poultry.

Hu Wei, General Manager of Luoyang Huizhong Biotechnology Co., Ltd.

Hu Wei, general manager of Huizhong Biological, said in a speech that the emergence of the new series of joint seedlings has made a significant contribution to the field of poultry seedlings in my country, and has made outstanding contributions to the prevention and control of industry diseases. In the future, Huizhong Biology will develop a series of genetically engineered vaccines combining Newcastle disease (gene VII), bursa of fabric (rVP2 protein), and adenovirus genetic engineering subunits, as well as water-based adjuvant vaccines for broilers. The pig vaccine was officially launched in October this year.

The general trend of genetic engineering vaccines

Zhang Xuke, Chairman of Plyco Bioengineering Co., Ltd.

my country’s animal husbandry industry is in a period of rapid development of intensive and branding, and the scale of the pig and poultry industry has increased significantly. Zhang Xuke, chairman of Plyco Bioengineering Co., Ltd. (hereinafter referred to as Plyco), believes that environmental protection pressure and food safety , Rising labor costs and economies of scale are the driving forces leading to these changes. Large-scale breeding groups and breeding cooperatives/family farms will become the main breeding methods in the future.

For the animal protection industry, the industry concentration has also continued to increase. In 2015, there were 88 biological products companies, of which the output value of the top 10 accounted for 71%, and the output value of the top 5 accounted for 48%; there were 1,720 chemical pharmaceutical companies in 2015. The output value of the top 30 accounts for 51%. In addition, industry restructuring and mergers and acquisitions have intensified, with strong companies acquiring relatively weak companies, or strong alliances, and competition for resource integration is fierce. Third, the integration of the industrial chain of enterprises has accelerated, and large enterprises have expanded from feed and animal husbandry to numerous examples. Fourth, technological innovation has become the consensus of industry development, and the number of new veterinary drug registration certificates has increased year by year.

In recent years, the joint-stock company has increased its scientific and technological innovation and achieved remarkable results. It has successively obtained 31 national new veterinary drug certificates, established 53 veterinary drug national standards, obtained more than 120 authorized invention patents, more than 390 invention patent applications, and obtained 10 national and provincial patents. Municipal Science and Technology Progress Award, becoming one of the giants in the animal protection industry.

Regarding Huizhong's future development strategy, Zhang Xuke introduced that a new generation of genetically engineered vaccines is an important direction for the company's development. In addition, efficient immune adjuvant technology, a new generation of high-throughput rapid diagnostic kits, and animal health management And the ecological circle of safe animal product production.

Tian Kegong, Director of National Engineering Research Center for Veterinary Medicines

Poultry vaccines have developed to the third generation of vaccines, namely genetic engineering technology + bioengineering technology. Tian Kegong, director of the National Veterinary Medicine Engineering Technology Research Center, introduced that genetic engineering vaccines are vaccines prepared by genetic engineering methods, that is, using genetic recombination technology. The vaccine prepared by inserting natural or artificial genetic material into other vectors such as bacteria to fully express it and then purify it. Compared with traditional vaccines, genetic engineering vaccines have the advantages of safety and broad spectrum. An emerging high-level biological product with broad application prospects is more conducive to making joint seedlings.

The Newcastle Disease Genotype VII series of inactivated vaccines are also developed using genetic engineering technology. The HI antibody has higher titer, less immune challenge and detoxification, and can also be made into double, triple, and quadruple vaccines. The chicken infectious bursal bursal subunit vaccine is not a difficult technology, but it is not common to make triple and quadruple vaccines. We assemble the bursal bursa subunit VP2 protein into virus-like particles to make a new flow method Triple inactivated vaccine. Adenovirus (group I type 4) series of inactivated vaccines, and inactivated vaccines for genetic engineering of new glands and new tributary glands have been declared for clinical use.

The new flow method is listed, the genetic engineering technology guarantees the effect

Launching Ceremony of New Flow Law Listing

Luo Guanqun, Director of Customer Marketing, Huizhong Biological Group

The rapid development of the white feather broiler breeding industry has accelerated scale, intensification, standardization, and factoryization. This has opened up the era of human-raised equipment and equipment-raised chickens. Feeding management, animal welfare, biological safety, and herd immunity are becoming more and more important.

Newcastle disease (ND), H9N2 subtype avian influenza and infectious bursal disease (IBD) are three important diseases that harm the poultry industry in my country and the world. According to Luo Guanqun, Customer Marketing Director of Huizhong Biological Group, the new-flow method genetic engineering subunit triple inactivated vaccine developed by Huizhong Biology has screened targeted strains and used genetic engineering techniques to express VP2 protein, which can be assembled into virus-like particles. Cellular immunity and humoral immunity of the body are added to the national "863" project research results-compound adjuvants to achieve one shot of three preventions, which fits the "scientific burden reduction" concept of "small dose, low frequency, high protection". A large number of white feather broilers, yellow feather broilers, 817 broiler chickens, laying hens, breeders and other poultry clinical field test results show that Huizhong's new flow method genetic engineering subunit triple inactivated vaccines are concentrated in 1-day-old hatcheries Immune to 0.15ml/feather, the immune effect is good, the immune stress is small, and the immune cost is low. Become a 1-day-old immune expert.

Song Guoliang, Chief Engineer of Huizhong Biotechnology

The quality of the vaccine is designed and produced. It comes from the company’s advanced production equipment, advanced process advantages and GMP management, etc. Huizhong Biological Chief Engineer Song Guoliang introduced that Huizhong Biological began to build a factory in 2013 and purchased a large amount of Advanced and automated production equipment provides a strong guarantee for improving production efficiency and ensuring product quality, and is a priority in the industry.

The goal of the company's products is to be safe, efficient, and quality controllable. This goal has been practiced in the process of R&D and production. The GMP production workshop is the same as the human medicine standard, and the production adopts imported fully automated equipment. Therefore, Huizhong Bio's products have: advanced technology, high automation of equipment, new characteristics of product strains, stable and uniform product quality, and are trustworthy and reliable. product.

Liu Changqing, Veterinary Officer, Beijing Huaduyukou Co., Ltd.

The current complex diseases in China have led to more and more complicated epidemic prevention procedures in various farms/bases. Clinical veterinarians have been doing “additions” and dare not do “subtractions”. This has led to more and more immunizations and types of poultry immunization prevention. And the burden of immune operators is getting heavier. The survey found that in most breeding enterprises, there are two problems in disease prevention and control: more and more, and less.

In the face of this situation, Liu Changqing, a veterinary officer of Beijing Huadu Yukou Co., Ltd., put forward the scientific burden reduction concept of "five reduction and two unavoidable" based on the "scientific burden reduction" theory of Academician Liu Xiufan of Yangzhou University and the actual situation of Yukou Company. They have formulated a scientific prevention and control plan based on the physiology of poultry, the law of disease occurrence and development, and the law of antibody growth and decline, to realize the subtractive operation of the immune program, which not only reduces the immune stress of the chickens, but also reduces the immune operation intensity and greatly reduces the cost of immunization50 %above. "Scientific load reduction by 12345" mainly refers to "one core, two principles, three laws, four supports, and five measures to reduce the burden to make chickens healthier."

Current epidemic trends and prevention and control strategies of poultry diseases

Wu Yangong, Director of China Animal Health and Epidemiological Surveillance Center

Avian influenza, Newcastle disease, and infectious bronchitis are the three epidemic diseases currently prevented and controlled by the poultry breeding industry. In addition, bacteria and mycotoxins are all important causes of disease in chickens. Wu Yangong, director of the China Animal Health and Epidemiological Surveillance Center, gave a detailed introduction to the current avian influenza epidemic trend and prevention and control strategies.

The epidemic situation this year has shown a prolonged trend. The annual bronchial blockage can end in early June, but it still occurs so far this year, and this year's bronchial blockage is mainly manifested as bronchial embolism, severe pulmonary edema and necrosis. And the symptoms of enteritis, the results of virus isolation showed that it was mainly H9 subtype avian influenza infection, followed by spreading and Newcastle disease. The results of bronchial embolism virus isolation from a broiler breeding group in Shandong showed that H9 accounted for 57.70%, IB accounted for 46.20%, and ND accounted for 30.80%, indicating that bronchial embolism in broilers this year was mainly caused by H9 subtype avian influenza. Researcher Wu introduced avian The causes and prevention and control measures of influenza H9 and other prevention and control measures for avian influenza, the management of temperature control and ventilation of the chicken house, and the use of targeted epidemic strains for immune prevention are the key to solving the problem.

Wei Ping, Professor, School of Animal Science and Technology, Guangxi University

The virulence and antigenicity of the bursal bursal virus have been mutated, and super-virulent strains have also appeared in the flock of chickens under the immune pressure of high-intensity and large-scale use of live bursal bursal vaccine. Studies have shown that viral gene recombination and viral virulence-related gene mutations are one of the main reasons for the complexity of the current IBD epidemic. The infection of the super-virulent strains leads to the expansion of the age range of the host's onset, the increase of morbidity and mortality, the insignificant disease performance, immunosuppression, serious immune failure and other consequences.

Wei Ping, a professor at the School of Animal Science and Technology of Guangxi University, believes that a comprehensive prevention and treatment plan that combines effective biosafety measures and vaccination is an effective way to control bursal disease. It is necessary to strengthen the disinfection and cleaning of the chicken farm environment, strengthen the feeding and management conditions of the chickens, and formulate a scientific immunization plan. Among them, the level of maternal antibodies must be monitored before the chicks are immunized. Causes damage to the vesicles; the immune effect of the inactivated vaccine in breeders is better. It is recommended to avoid the inactivated vaccine again after the peak period of egg production, which provides a strong guarantee for the chicks to obtain high levels of maternal antibodies.

In order to thank the new and old customers, Huizhong Bio-Bio held a sumptuous thank-you dinner and self-written and self-directed cultural programs at Yaxiang Jinling Hotel. The Huizhong Bio-team fully interacted with the participating customers. "Scientific burden reduction and win-win cooperation"-Huizhong Biology's new model of cost-saving and efficiency-enhancing immunization and the launch of the new flow method came to a successful conclusion.